Haemodynamics, fluids & transfusion
Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines
Methodological detailsGrading of Recommendations Assessment Development and Evaluation (GRADE) methodology
- GRADE methodology
Recommendations
As issued by the authors
- Strong, high/moderate-certainty evidence
Hypoproliferative thrombocytopenia in nonbleeding patients receiving chemotherapy or undergoing allogeneic stem cell transplant: transfuse when platelet count <10 × 103/μL
- Strong, high/moderate-certainty evidence
Consumptive thrombocytopenia in neonates without major bleeding: transfuse when platelet count <25 × 103/μL
- Strong, high/moderate-certainty evidence
Lumbar puncture: transfuse when platelet count <20 × 103/μL
- Strong, high/moderate-certainty evidence
Consumptive thrombocytopenia due to Dengue without major bleeding: platelet transfusion not recommended
- Conditional, low/very low-certainty evidence
Hypoproliferative thrombocytopenia in nonbleeding adults undergoing autologous stem cell transplant or with aplastic anemia: prophylactic platelet transfusion not recommended
- Conditional, low/very low-certainty evidence
Adults with consumptive thrombocytopenia without major bleeding: transfuse when platelet count <10 × 103/μL
- Conditional, low/very low-certainty evidence
Adults undergoing central venous catheter placement in compressible anatomic sites: transfuse when platelet count <10 × 103/μL
- Conditional, low/very low-certainty evidence
Adults undergoing interventional radiology: transfuse when platelet count <20 × 103/μL for low-risk and <50 × 103/μL for high-risk procedures
- Conditional, low/very low-certainty evidence
Adults undergoing major nonneuraxial surgery: transfuse when platelet count <50 × 103/μL
- Conditional, low/very low-certainty evidence
Patients without thrombocytopenia undergoing cardiovascular surgery without major hemorrhage, incl. CPB: platelet transfusion not recommended
- Conditional, low/very low-certainty evidence
Nonoperative intracranial hemorrhage in adults with platelet count >100 × 103/μL, incl. antiplatelet agents: platelet transfusion not recommended
Original publication
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