Haemodynamics, fluids & transfusion
Platelet Transfusion before central venous catheter (CVC) Placement in Patients with Thrombocytopenia
Primary resultResult — go to the resultRelative risk 2.45 90% CI 1.27–4.70Authors' conclusion
The withholding of prophylactic platelet transfusion before CVC placement in patients with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority and resulted in more CVC-related bleeding events than prophylactic platelet transfusion.
Study context
- Population
- Patients with severe thrombocytopenia (platelet count 10,000 to 50,000 per cubic millimeter) on the hematology ward or in the ICUepisodes in 338 patients
- Participants
- 373 patients
- Comparison
- No transfusion vs Transfusion
- Transfusionn = 188reference
- No transfusionn = 185
- Primary endpoint
- Catheter-related bleeding of grade 2 to 4
Methodological detailsmulticentre, noninferiority
- Multicentre
- Noninferiority
Primary result
As reported in the abstract
Relative risk
2.45
90% CI 1.27–4.70
Events by treatment group
No transfusion vs Transfusion
RR 2.45 (90% CI 1.27–4.70)
Secondary outcomes
| Outcome | Transfusion | No transfusion | RR (95% CI) | |
|---|---|---|---|---|
| Catheter-related bleeding grade 3 or 4 (key secondary) | 2.1% | 4.9% | 2.43 (0.75–7.93) | |
| 0.10.31310Relative risk (log scale) |
Net savings of withholding prophylactic platelet transfusion
- Net savings per catheter placement
- $410
Safety
Events
| Outcome | Transfusion | No transfusion |
|---|---|---|
| Adverse events | 4 | 9 |
- Adverse events — Total adverse events
- 15
- Adverse events — Serious adverse events (all grade 3 catheter-related bleeding)
- 13
- Adverse events: per-group counts are serious events (grade 3 catheter-related bleeding)
Original publication
Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia. N Engl J Med. Published 25 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →