Neuroanaesthesia & neurocritical care

Point-of-Care EEG Artificial Intelligence Measure of Seizure Burden Associates With Clinical Outcome at Discharge

Crit Care MedPublished Secondary cohort analysis of the retrospective multicenter SAFER-EEG study

Authors' conclusion

AI-estimated SzB is associated with functional outcomes at discharge in a dose-response fashion, even after controlling for clinical cofounds.

Study context

Population
Adults monitored with point-of-care EEG at three academic centers359 with complete data
Participants
400 adults
Comparison
Artificial intelligence (AI)-estimated seizure burden and outcome
Methodological detailsmulticentre
  • Multicentre

Primary result

As reported in the abstract

Unfavorable outcome (modified Rankin Scale (mRS) > 3) at discharge · discharge

Per additional hour of seizure (bedside algorithm), aOR

1.98

95% CI 1.11–4.29

Peak 5-min seizure burden (SzB) ≥ 90% vs 0% (bedside algorithm), fold increase in aOR of poor outcome

3.4

Per 30 seconds of activity in maximum hourly SzB (bedside algorithm), aOR

1.02

95% CI 1.00–1.03

Combined algorithms, peak 5-min SzB ≥ 90%, aOR

4.4

95% CI 1.66–12.69

Further findings

Peak 5-min SzB > 0% (bedside algorithm)

Patients with peak 5-min SzB > 0%
39.8%

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Point-of-Care EEG Artificial Intelligence Measure of Seizure Burden Associates With Clinical Outcome at Discharge. Crit Care Med. Published 1 June 2026. doi:10.1097/ccm.0000000000007158

Composed by AI from the published abstract and checked against it. How Briefs are made →

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