Perioperative medicine & outcomes
Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study
Authors' conclusion
Standardized polygenic risk was associated with PONV in all three of the study's models, but the genetic influence was smaller than exerted by clinical risk factors.
Study context
- Population
- Surgeries under GA with integrated genetic and perioperative data at Michigan Medicine and Vanderbilt University Medical Center
- Participants
- 64,523 participants
- Comparison
- Polygenic score added to clinical risk models for postoperative nausea and vomiting (PONV) prediction
- Outcome
- PONV (nausea or emesis documented in the PACU)
Methodological detailsgenome-wide association study, meta-analysis of cohorts, multicentre
- Genome-wide association study
- Meta-analysis of cohorts
- Multicentre
Performance
As reported in the abstract
Association of standardized polygenic score with PONV
Estimate (95% CI)P value
Polygenic score, basic model (age, sex)
aOR per SD increase 1.027(1.001–1.053)
P = 0.044Polygenic score, known clinical risks model
aOR 1.029(1.003–1.055)
P = 0.030Polygenic score, full clinical regression (21 factors)
aOR 1.029(1.002–1.056)
P = 0.033- PONV incidence
- 5,703 (8.8%)
- Genetic variants exceeding P < 1 × 10-5, minor allele frequency >1%, concordant in both cohorts
- 46
Further findings
Discrimination with polygenic score added to known clinical risk factor models
- C-statistic with vs without polygenic score
- 0.616 compared to 0.613; P = 0.028
- Net reclassification improved
- 4.6% of cases
Original publication
Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study. Anesthesiology. Published 9 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →