Perioperative medicine & outcomes
Clinical and genetic factors associated with post‐operative nausea and vomiting after propofol anaesthesia
Authors' conclusion
Our GWAS approach did not identify any high-impact PONV susceptibility variants. The results provide some support for a role of dopamine D2 receptors in PONV.
Study context
- Population
- Women with elevated post-operative nausea and vomiting (PONV) risk undergoing breast cancer surgery with standardised propofol anaesthesia and antiemetics, Helsinki University Hospital, 2006–20101,000 enrolled
- Participants
- 815 women
- Comparison
- PONV cases vs controls
- PONV casesn = 187
- Controlsn = 628reference
- Outcome
- PONV
- Follow-up
- 2-24 h after surgery
Methodological detailsgenome-wide association study, single-centre
- Genome-wide association study
- Single-centre
Main finding
As reported in the abstract
PONV incidence
PONV at 2-24 h after surgery
23%
Observational data: associations, not effects.
Further findings
Overall PONV incidence · up to 7th POD
- Overall PONV incidence
- 35%
- PONV at 0-2 h
- 3%
Clinical predictors of PONV (logistic model)
- Model ROC-AUC
- 0.75 (95% CI 0.71-0.79)
- Significant predictors: age, ASA status, oxycodone amount in PACU, smoking status, previous PONV, history of motion sickness
Genome-wide association study (GWAS) (653 034 variants)
- Variants with suggestive association to PONV (p < 1 × 10-5 )
- 6
Replication of previously reported variants (31 variants in 16 genes)
- Association with DRD2 variant rs18004972 (TaqIA) replicated
- P = 0.028
Original publication
Clinical and genetic factors associated with post‐operative nausea and vomiting after propofol anaesthesia. Acta Anaesthesiol Scand. Published 8 May 2023. doi:10.
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