Population-based multistate modelling of peritraumatic opioid use among trauma patients from the Norwegian Trauma Registry
Authors' conclusion
In our cohort, most patients with posttraumatic long-term opioid use had used opioids before injury, underscoring the need to address such use to minimise posttraumatic long-term opioid use.
Study context
- Population
- Trauma patients in the Norwegian Trauma Registry, 2015–2018 cohorts, linked to Norwegian Prescription Database (1 yr before to 2 yr after injury)
- Participants
- 24,224 patients
- Outcome
- Peritraumatic opioid use: long-term opioid use (LTU; ≥900 MME within 90 days and another opioid prescription 91-180 days after any initial prescription) and short-term opioid use (STU)
Methodological detailsmultistate model, registry linkage
- Multistate model
- Registry linkage
Main finding
As reported in the abstract
Peritraumatic opioid use
Peak STU after injury
38.2%
STU returned to pre-injury level within 6 months
5.4%
Increase in LTU (from to)
4.3% to 6.7%
Observational data: associations, not effects.
Further findings
Patients with LTU in the year after injury (subgroup)
- Patients with LTU in year after injury
- 1946
- LTU in 6 months pre-injury
- 47.4%
- STU in 6 months pre-injury
- 18.3%
- Reimbursed for chronic pain medications
- 36.0%
- Reimbursed for palliative care
- 5.9%
- Received opioid maintenance treatment
- 13.1%
Original publication
Population-based multistate modelling of peritraumatic opioid use among trauma patients from the Norwegian Trauma Registry. Br J Anaesth. Published 4 July 2025. doi:10.
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