Paediatric anaesthesia & critical care
Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery
Authors' conclusion
Postoperative cefazolin concentrations in paediatric patients undergoing cardiopulmonary bypass are often inadequate to maintain optimal antimicrobial prophylaxis.
Study context
- Population
- Paediatric patients undergoing cardiac surgery with CPB receiving cefazolin prophylaxisincluded in PK model
- Participants
- 68 patients
- Outcome
- Unbound cefazolin concentrations above the MIC for 100% of the dosing interval (fT>MIC), intraoperative and postoperative
Methodological detailssingle-centre, population pharmacokinetic modelling, dosing simulations
- Single-centre
- Population pharmacokinetic modelling
- Dosing simulations
Main finding
As reported in the abstract
Target attainment with conventional dosing (preop 50 mg/kg, intraop 25 mg/kg 3-hourly, postop 25 mg/kg 8-hourly) · postoperative
Subtherapeutic concentrations postoperatively in up to this proportion of patients
16.8%
Observational data: associations, not effects.
Original publication
Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery. Anaesth Crit Care Pain Med. Published 29 October 2025. doi:10.
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