Respiratory failure & ventilation
Population-wise incidence and outcomes of patients requiring invasive and non-invasive mechanical ventilation in China: a nationwide retrospective analysis by age, sex, and comorbidity
Authors' conclusion
Mortality rates were markedly higher among patients receiving IMV compared to those receiving NIV, with the differences most pronounced among elderly patients, males, and those with greater comorbidity burden.
Study context
- Population
- Hospitalised patients receiving mechanical ventilation in China, admitted January 1–December 31, 2022 (National Data Center for Medical Service)admissions, 2,837 hospitals
- Participants
- 1,641,809 patients
- Exposure
- Invasive mechanical ventilation (IMV) only vs non-invasive ventilation (NIV) only
- Outcome
- Incidence, characteristics and in-hospital case fatality of mechanical ventilation
Methodological detailsmulticentre, retrospective, nationwide
- Multicentre
- Retrospective
- Nationwide
Main finding
As reported in the abstract
In-hospital case fatality
- Overall in-hospital death among mechanically ventilated patients
- 12.8%
- Incidence of mechanical ventilation per 100,000 population
- 186.5
- IMV only
- 64.4%
- NIV only
- 29.0%
Observational data: associations, not effects.
Further findings
Patient characteristics and comorbidity
- Median age, years (IQR 51.0-76.0)
- 66.0
- Cerebrovascular disease among invasively ventilated patients
- 41.4%
- Chronic pulmonary disease in NIV patients (most common comorbidity)
- 57.0%
- IMV only: longer hospital stays and higher comorbidity burden vs NIV
NIV failure rate
- NIV failure rate
- 7.9%
Mortality by age and Charlson index (subgroup)
- Increasing age and higher Charlson index associated with stepwise increase in mortality risk
Original publication
Population-wise incidence and outcomes of patients requiring invasive and non-invasive mechanical ventilation in China: a nationwide retrospective analysis by age, sex, and comorbidity. Ann Intensive Care. Published 14 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →