Perioperative medicine & outcomes
Postoperative Aspiration Pneumonia Among Adults Using GLP-1 Receptor Agonists
Main findingResult — go to the resultOdds ratio 0.78 95% CI 0.57–1.06Authors' conclusion
This cohort study found no significant association between the preoperative use of GLP-1 RAs and short-term postoperative aspiration pneumonia despite growing concerns about the adverse effects of these medications after surgery.
Study context
- Population
- Adults undergoing 1 of 14 common surgical procedures, April 2020–September 2022; excluded multiple procedures or pneumonia/acute respiratory failure in prior 90 days
- Participants
- 366,476 adults
- Exposure
- Preoperative GLP-1 RA use vs nonuse
- GLP-1 RA usersn = 5,931
- Outcome
- Aspiration pneumonia
- Follow-up
- 30-day postoperative period
Methodological detailsclaims database (MarketScan), multivariable logistic regression
- Claims database (MarketScan)
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio
0.78
95% CI 0.57–1.06
P = 0.12
GLP-1 RA users vs Nonusers
OR 0.78 (95% CI 0.57–1.06); P = 0.12
Observational data: associations, not effects.
Original publication
Postoperative Aspiration Pneumonia Among Adults Using GLP-1 Receptor Agonists. JAMA Netw Open. Published 3 March 2025. doi:10.
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