Perioperative medicine & outcomes
Perioperative anesthesia management of GLP-1 receptor agonists: a systematic review of potential risks
Authors' conclusion
Although most of the studies reported an association between GLP-1 RA and increased residual gastric contents, evidence linking these medications to a statistically significant rise in regurgitation or aspiration events remains highly inconsistent.
Study context
- Population
- Perioperative patients taking GLP-1 receptor agonists32 articles
- Comparison
- GLP-1 RA use vs no use
- Outcome
- Regurgitation and aspiration events
Methodological detailsPRISMA, Search of PubMed, Google Scholar, SCOPUS, MEDLINE and EMBASE from inception to January 17, 2025
- PRISMA
- Search of PubMed, Google Scholar, SCOPUS, MEDLINE and EMBASE from inception to January 17, 2025
Pooled result
As reported in the abstract
- Most studies reported an association between GLP-1 RA and increased residual gastric contents
- Evidence linking GLP-1 RAs to a statistically significant rise in regurgitation or aspiration events highly inconsistent
Original publication
Perioperative anesthesia management of GLP-1 receptor agonists: a systematic review of potential risks. Perioper Med (Lond). Published 21 February 2026. doi:10.
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