Postoperative quality of recovery comparison between ciprofol and propofol in total intravenous anesthesia for elderly patients undergoing laparoscopic major abdominal surgery: A randomized, controlled, double-blind, non-inferiority trial

Liang, Z; Liu, J; Chen, S; Zhao, X; Chen, G; Xie, Y; Wang, D; Xing, F; Mao, Y; Zhang, W; Wang, Z; Yuan, J

doi:10.1016/j.jclinane.2024.111660

Anesthetic drugs & techniques

Postoperative quality of recovery comparison between ciprofol and propofol in total intravenous anesthesia for elderly patients undergoing laparoscopic major abdominal surgery: A randomized, controlled, double-blind, non-inferiority trial

J Clin AnesthPublished 18 Oct 2024Randomised controlled trial

Primary result · QoR-15, ITT setResultMean difference 0.4 95 % CI −2.8-3.5

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Authors' conclusion

Ciprofol is not inferior to propofol in QoR.

Study context

Population: Elderly patients (age ≥ 65 years) undergoing elective laparoscopic major abdominal surgery
Participants: 144 patients

Comparison: Ciprofol vs propofol total intravenous anesthersia (TIVA)
Primary endpoint: QoR-15 score (non-inferiority threshold for mean difference −8)
Follow-up: POD1

Methodological detailsprospective, double-blind, non-inferiority

Prospective
Double-blind
Non-inferiority

Primary result

QoR-15, ITT set

Mean difference

0.4

95 % CI −2.8-3.5

P < 0.001 for non-inferiority

By group

Ciprofol

95.9

mean · 95% CI 93.7–98.2

Propofol

95.6

mean · 95% CI 93.3–97.8

Ciprofol vs Propofol

mean difference 0.4 (95 % CI −2.8-3.5); P for non-inferiority < 0.001

As reported in the abstract

Further findings

Mean

Outcome	Ciprofol	Propofol	← Lower with ciprofol ←→ Higher with ciprofol →	Mean difference (95 % CI)	P value
QoR-15, per-protocol set · POD1Non-inferior · per-protocol	96.7 (95% CI 94.4–99.0)	95.7 (95% CI 93.4–98.0)	−4−20246	1.0 (−2.2-4.3)	P for non-inferiority < 0.001
			−4−20246Difference (linear scale)

QoR-15 on POD2, 3 and 5 (both analysis sets)

Comparable outcomes in both analysis sets

Safety

Injection pain · lower with ciprofol · intention-to-treat

P < 0.001

Ciprofol2.8 %

Propofol27.8 %

Hypotension · less frequent with ciprofol

P = 0.012

Ciprofol33.3 %

Propofol54.2 %

Bradycardia · more common with ciprofol

P = 0.048

Ciprofol38.9 %

Propofol23.6 %

Original publication

Postoperative quality of recovery comparison between ciprofol and propofol in total intravenous anesthesia for elderly patients undergoing laparoscopic major abdominal surgery: A randomized, controlled, double-blind, non-inferiority trial. J Clin Anesth. Published 18 October 2024. doi:10.1016/j.jclinane.2024.111660

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