Perioperative medicine & outcomes
Postoperative sepsis and its sequential impact on dementia
Main finding · DementiaResult — go to the resultHazard ratio 1.25 95% CI 1.03–1.52Authors' conclusion
Postoperative sepsis is significantly associated with increased dementia risk in a dose-dependent manner.
Study context
- Population
- Surgical patients without prior dementia, National Database in Taiwan, surgeries 2008–2013 (data 2005–2022)after propensity score matching (PSM)
- Participants
- 778 vs 3,112
- Exposure
- Postoperative sepsis vs no postoperative sepsis
- Postoperative sepsisn = 778
- Non-postoperative sepsisn = 3,112reference
- Outcome
- Dementia incidence
Methodological details1:4 propensity-score matched, national database, landmark analysis (12 months after surgery), Fine-Gray competing risk model
- 1:4 propensity-score matched
- National database
- Landmark analysis (12 months after surgery)
- Fine-Gray competing risk model
Main finding
Dementia
Hazard ratio
1.25
95% CI 1.03–1.52
By group
Postoperative sepsis vs Non-postoperative sepsis
HR 1.25 (95% CI 1.03–1.52)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Dementia by number of postoperative sepsis events (dose-response)
| HR (95% CI) | ||
|---|---|---|
| Two or more events | 1.77 (1.17–2.66) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Postoperative sepsis | Non-postoperative sepsis | HR (95% CI) | |
|---|---|---|---|---|
| Mortality | 40.5% | 31.6% | 1.45 (1.28–1.65) | |
| 0.512Hazard ratio (log scale) |
- Dementia by number of postoperative sepsis events (dose-response): One event 24.5%
- Dementia by number of postoperative sepsis events (dose-response): Two or more events 34.9%
Original publication
Postoperative sepsis and its sequential impact on dementia. Crit Care. Published 6 February 2025. doi:10.
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