Perioperative medicine & outcomes
Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA
Authors' conclusion
We found no evidence of synergistic thrombotic risk from previous COVID-19 in patients who underwent selected major surgery relative to the baseline thrombotic risk from surgery alone.
Study context
- Population
- Commercially insured adults in the US, Optum Labs Data Warehouse, March 2020 to June 2021
- Participants
- Two million and two-hundred thousand eligible patients
- Exposure
- Surgery, prior COVID-19 vs Surgery, no COVID-19 vs No surgery
- Outcome
- Perioperative thrombotic events (VTE and MACE); interaction of surgery and previous COVID-19
- Follow-up
- Within 90 days
Methodological detailsmultivariable logistic regression, interaction analysis
- Multivariable logistic regression
- Interaction analysis
Main finding
As reported in the abstract
Perioperative thrombotic events
Adjusted odds ratio (95% CI)
Surgical exposureCOVID-19 history not associated after adjustment
4.07(3.81–4.36)
Surgery × prior COVID-19 (multiplicative interaction term)
1.25(0.96–1.61)
- Surgery × prior COVID-19
- synergy index 0.76 (95% CI 0.56–1.04)
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Surgical cohorts older and more medically complex than nonsurgical controls
Original publication
Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA. Can J Anaesth. Published 15 December 2023. doi:10.
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