Respiratory failure & ventilation
Potentially modifiable ventilatory factors contributing to outcome in patients with pulmonary and extrapulmonary ARDS — An individual patient data analysis
Authors' conclusion
High ΔP and high RR were associated with 60-day mortality in patients with pulmonary and extrapulmonary ARDS receiving mechanical ventilation, with ΔP showing a stronger association in pulmonary ARDS compared with extrapulmonary ARDS.
Study context
- Population
- Mechanically ventilated patients with pulmonary or extrapulmonary ARDS
- Participants
- 7,934 participants · 6 observational studies
- Comparison
- Pulmonary ARDS vs Extrapulmonary ARDS
- Outcome
- Mortality
- Follow-up
- Day 60 after inclusion
Pooled result
As reported in the abstract
60-day mortality · day 60
- Did not survive
- 3402 (43%)
- Interaction etiology × ΔP: stronger association in pulmonary vs extrapulmonary ARDS
- p < 0.001
Further pooled results
60-day mortality, excluding COVID-19 patients (sensitivity analysis)
- Respiratory rate no longer associated; ΔP remained associated
Original publication
Potentially modifiable ventilatory factors contributing to outcome in patients with pulmonary and extrapulmonary ARDS — An individual patient data analysis. J Clin Anesth. Published 17 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →