ICU sedation, delirium & recovery
Pre-admission prescription of selective serotonin reuptake inhibitors and mortality in critical illness: a national cohort study from 2020 to 2023
Authors' conclusion
Pre-admission SSRI prescription was associated with lower short- and intermediate-term mortality in critically ill adults.
Study context
- Population
- Adults with a first intensive care unit (ICU) admission in South Korea, 2020–2023
- Exposure
- Pre-admission selective serotonin reuptake inhibitor (SSRI) prescription vs none
- Outcome
- 30-day and 90-day mortality
Methodological detailsnationwide, propensity-score matched
- Nationwide
- Propensity-score matched
Main finding
As reported in the abstract
- Pre-admission SSRI prescription associated with lower 30-day and 90-day mortality
- Propensity score matched
Observational data: associations, not effects.
Further findings
Full cohort and prescription coverage incl. the day before ICU admission (sensitivity analyses)
- Similar associations observed
Patients with documented psychiatric disorders (subgroup)
- Associations appeared stronger
Original publication
Pre-admission prescription of selective serotonin reuptake inhibitors and mortality in critical illness: a national cohort study from 2020 to 2023. Ann Intensive Care. Published 17 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →