Cardiothoracic & vascular anesthesia
Pre‐operative reference ranges for ROTEM ® sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts
Authors' conclusion
Reference ranges for patients undergoing cardiac surgery differed from the manufacturer reference ranges. Pre-operatively, female patients exhibited a slightly more hypercoagulable ROTEM profile than males when comparing medians, though the reference ranges were similar. No differences were found across age categories.
Study context
- Population
- Adult patients undergoing cardiac surgery, single centre in the Netherlands
- Participants
- 381 patients
- Comparison
- Pre-operative ROTEM sigma reference ranges in cardiac surgery patients vs manufacturer reference ranges; males vs females; age quartiles
- Malesn = 260
- Femalesn = 121
- Primary endpoint
- Pre-operative ROTEM sigma reference ranges (2.5-97.5th percentiles) compared with manufacturer ranges
- Follow-up
- Pre-operative
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Reference ranges vs manufacturer
- EXTEM and FIBTEM clot firmness upper limits higher than manufacturer
- Clotting time ranges in EXTEM and INTEM wider than manufacturer
- Lower limit of LI60 EXTEM lower than manufacturer
- Non-overlapping 95%CIs indicated significant difference
Further findings
Sex-specific variation (subgroup)
- Females had shorter CT EXTEM and higher A5, A10 and MCF in EXTEM and FIBTEM, but reference ranges not significantly different
Age-specific variation (four age categories by quartiles)
- No differences in medians or reference bounds across age categories
Original publication
Pre‐operative reference ranges for ROTEM ® sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts. Anaesthesia. Published 15 April 2025. doi:10.
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