Predictive validity of daily sequential organ failure assessment (SOFA)-2 score for 30-day mortality
Authors' conclusion
SOFA-2 provided modestly better discrimination for 30-day mortality on ICU-day 1 compared with SOFA-1.
Study context
- Population
- Adults admitted to four ICUs in Sweden, 2010–2021
- Participants
- 29,820 admissions
- Exposure
- SOFA-2 vs SOFA-1 for prediction of 30-day mortality
- Outcome
- Predictive validity (AUROC) for 30-day mortality
- Follow-up
- ICU day 1
Methodological detailsmulticentre (four ICUs)
- Multicentre (four ICUs)
Main finding
As reported in the abstract
AUROC for 30-day mortality · Day 1
SOFA-2
0.81
95% CI 0.80–0.81
SOFA-1
0.80
95% CI 0.79–0.81
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Day-1 AUROC, sepsis (subgroup) | SOFA-2 0.72 (95% CI 0.70–0.74) |
- Day-1 AUROC, sepsis (subgroup): mean age 61 years; median CCI 3
AUROC for 30-day mortality, days 2–7 · From day 2 onward
- AUROCs declined for both scores and were largely similar
Reclassification between SOFA-1 and SOFA-2 · Days 1-7
- Admissions reclassified
- 75-79%
Day-1 AUROC, trauma (subgroup)
- Comparable performance for SOFA-1
- Mean age 50 years; median CCI 0
Day-1 AUROC, sepsis (subgroup)
- Comparable performance for SOFA-1
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Predictive validity of daily sequential organ failure assessment (SOFA)-2 score for 30-day mortality. Crit Care. Published 1 June 2026. doi:10.
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