Automated Calculation of Sequential Organ Failure Assessment ( Sequential Organ Failure Assessment (SOFA) ) Score in the Intensive Care Unit: Algorithm Development, Validation, and Association With 30‐Day Mortality
Main finding · Validation of full SOFA score (ICC)Result — go to the resultICC 0.99 95% CI 0.98–1.00Authors' conclusion
A trustworthy automated SOFA score dataset can be produced with comprehensive high-frequency electronic health records curation and rigorous artifact control, with accuracy comparable to manual scoring by senior intensivists.
Study context
- Population
- Adults admitted to four intensive care unit (ICUs) at the Karolinska University Hospitals, 2015–2018
- Participants
- 6,953 ICU admissions
- Exposure
- Automated vs manual SOFA scoring
- Outcome
- Agreement of automated vs manual SOFA score (ICC) on 300 randomly chosen ICU days
Methodological detailsmulticentre, algorithm development and validation
- Multicentre
- Algorithm development and validation
Main finding
Validation of full SOFA score (ICC)
ICC
0.99
95% CI 0.98–1.00
As reported in the abstract
Observational data: associations, not effects.
Further findings
30-day mortality prediction (AUROC), remaining cohort
- Maximum SOFA score, AUROC
- 0.79 (95% CI 0.78-0.81)
- SOFA score on Day 2, AUROC
- 0.79 (95% CI 0.77-0.80)
- Best predictive abilities
Original publication
Automated Calculation of Sequential Organ Failure Assessment ( SOFA ) Score in the Intensive Care Unit: Algorithm Development, Validation, and Association With 30‐Day Mortality. Acta Anaesthesiol Scand. Published 15 February 2026. doi:10.
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