Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score: A Consensus Statement
Errata to this article were published (JAMA Netw Open, 2 Jan 2026 ↗ · 2 Mar 2026 ↗)
Authors' conclusion
Through a methodologically robust development process, the SOFA-2 score offers updated definitions to describe organ dysfunction in adult patients requiring critical care and readily quantifiable criteria to grade the degree of dysfunction in individual organ systems.
Study context
- Population
- Critically ill adult patients requiring critical careexperts, 65 countries
- Participants
- 60 patients
- Outcome
- SOFA-2 score development
Methodological detailsexpert task force, Delphi processes, systematic reviews and meta-analysis, 2 validation exercises, Variables tested in 2 validation exercises, separate datasets totaling 3.34 million patients in 10 databases; predictive validity = ICU discharge mortality
- Expert task force
- Delphi processes
- Systematic reviews and meta-analysis
- 2 validation exercises
- Variables tested in 2 validation exercises, separate datasets totaling 3.34 million patients in 10 databases; predictive validity = ICU discharge mortality
Recommendations
As reported in the abstract
Experts participating
60
Female participants
18
30%
Countries represented
65
Original publication
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score: A Consensus Statement. JAMA Netw Open. Published 1 October 2025. doi:10.
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