Hemodynamics, fluids & transfusion
Predictive value of dynamic arterial elastance for vasopressor withdrawal: a systematic review and meta-analysis
Authors' conclusion
Eadyn, evaluated through subgroup analyses, demonstrated good predictive ability for the discontinuation of vasopressor support in critically ill patients.
Study context
- Population
- Critically ill adults in the ICU receiving norepinephrine, regardless of diagnosis (76% septic shock)
- Participants
- 183 adults · 5 studies
- Comparison
- Dynamic arterial elastance (Eadyn) for predicting hypotension during vasopressor weaning
- Outcome
- Predictive performance of Eadyn for hypotension during vasopressor weaning
Methodological detailsprospective observational studies, PRISMA
- Prospective observational studies
- PRISMA
Pooled result
As reported in the abstract
Pooled accuracy of Eadyn for predicting hypotension on vasopressor withdrawal
Pooled AUC
0.85
Pooled sensitivity
0.87
95% CI 0.74–0.93
Pooled specificity
0.76
95% CI 0.68–0.83
Diagnostic OR
19.07
95% CI 8.47–42.92
Further pooled results
Subgroups by norepinephrine dose, measurement device, diagnostic cutoff (subgroup)
- No variations in Eadyn by norepinephrine dosage, measurement device or diagnostic cutoff
Original publication
Predictive value of dynamic arterial elastance for vasopressor withdrawal: a systematic review and meta-analysis. Ann Intensive Care. Published 9 July 2024. doi:10.
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