Cardiothoracic & vascular anesthesia
A norepinephrine weaning strategy using dynamic arterial elastance is associated with reduction of acute kidney injury in patients with vasoplegia after cardiac surgery: A post-hoc analysis of the randomized SNEAD study.
Authors' conclusion
Decreasing norepinephrine exposure by using a dynamic arterial elastance guided norepinephrine weaning strategy was associated with a reduced incidence of acute kidney injury in patients with vasoplegia after cardiac surgery.
Study context
- Population
- Vasoplegic cardiac surgical patients treated with norepinephrine, tertiary care hospital in Franceanalysed
- Participants
- 118 patients
- Comparison
- Dynamic arterial elastance-guided norepinephrine weaning vs control
- Primary endpoint
- Number of patients with AKI (KDIGO criteria)
- Follow-up
- First seven post-operative days
Methodological detailspost-hoc analysis, monocentric
- Post-hoc analysis
- Monocentric
Primary result
As reported in the abstract
AKI
P = 0.12
Secondary outcomes
Acute kidney injury (AKI) overall and by severity
- AKI, overall population
- 46 (39%)
- Kidney Disease Improving Global Outcomes (KDIGO) 1
- 30
- KDIGO 2
- 8
- KDIGO 3
- 8
- RRT required
- 6
Norepinephrine exposure and AKI severity
- Higher dose and longer duration of norepinephrine associated with AKI severity
Original publication
A norepinephrine weaning strategy using dynamic arterial elastance is associated with reduction of acute kidney injury in patients with vasoplegia after cardiac surgery: A post-hoc analysis of the randomized SNEAD study. J Clin Anesth. Published 24 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →