Cardiothoracic & vascular anesthesia
Oxiris Filter Therapy in Vasoplegic Shock After Cardiac Surgery: A Single-Center Retrospective Study
Main findingResult — go to the resultMean difference −18.9 95% CI −37.3 to −0.4Authors' conclusion
Oxiris filter therapy was associated with a significantly greater reduction in vasoactive inotropic support compared to standard CRRT filters in patients with vasoplegia following cardiac surgery.
Study context
- Population
- Patients with vasoplegia (cardiac index ≥2.2 L/min/m², norepinephrine ≥0.60 µg/kg/min for MAP ≥65 mmHg) needing continuous renal replacement therapy (CRRT) within 24 hours after cardiac surgery, tertiary cardiothoracic ICUcardiac transplantation most common surgery
- Participants
- Fifty-eight patients
- Exposure
- Oxiris hemadsorption filter vs standard CRRT filter
- Oxirisn = 30
- Controln = 28reference
- Outcome
- Change in vasoactive inotropic score (VIS), linear regression adjusted for baseline variables
- Follow-up
- 48 hours after start of CRRT
Methodological detailsinvestigator-initiated, single-centre
- Investigator-initiated
- Single-centre
Main finding
As reported in the abstract
Mean difference
−18.9
95% CI −37.3 to −0.4
P = 0.045
Oxiris vs control
mean difference −18.9 (95% CI −37.3 to −0.4); P = 0.045
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Mean group difference (µg/kg/min) (95% CI) | P value | |
|---|---|---|---|
| Norepinephrine dose | −0.19 (−0.35 to −0.03) | P = 0.019 | |
| −0.4−0.200.2Difference, µg/kg/min (linear scale) |
Hemodynamic parameters, fluid balance, ICU stay, 30-day mortality
- No significant differences
Original publication
Oxiris Filter Therapy in Vasoplegic Shock After Cardiac Surgery: A Single-Center Retrospective Study. J Cardiothorac Vasc Anesth. Published 30 January 2026. doi:10.
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