Cardiothoracic & vascular anaesthesia

Predictors and prognostic value for in-hospital outcomes associated with postoperative anemia in cardiac surgery: a retrospective cohort study

Can J AnaesthPublished Retrospective cohort study

Authors' conclusion

Postoperative anemia was common and independently associated with AKI and prolonged LOS after adjusting for preoperative anemia, intraoperative transfusion, and other confounders.

Study context

Population
Consecutive adults undergoing elective cardiac surgery, Toronto General Hospital, Canada, 2016–2021single centre
Participants
4,633 adults
Exposure
Postoperative anemia vs no postoperative anemia
  • Postoperative anemian = 2,232
Outcome
Predictors of postoperative anemia and its independent effect on in-hospital outcomes
Methodological detailssingle-centre, consecutive patients, multivariable regression
  • Single-centre
  • Consecutive patients
  • Multivariable regression

Main finding

As reported in the abstract

Postoperative anemia (nadir hemoglobin < 100 g·L-1 on POD 1) · POD 1

Postoperatively anemic

48%

2,232 events

Observational data: associations, not effects.

Secondary outcomes

OutcomeEstimateP value
AKIAfter adjustmentaOR 1.67 (95% CI 1.21–2.30)P < 0.01
LOSAfter adjustmentadjusted ratio of means 1.05 (95% CI 1.00–1.09)P < 0.05

Mortality, stroke, composite of ≥ stage 2 acute kidney injury (AKI), stroke and mortality

Postoperative anemia not independently associated with mortality, stroke or the composite outcome

Original publication

Predictors and prognostic value for in-hospital outcomes associated with postoperative anemia in cardiac surgery: a retrospective cohort study. Can J Anaesth. Published 22 May 2026. doi:10.1007/s12630-026-03126-2

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