Pediatric anesthesia & critical care
Predictors of Perioperative Respiratory Adverse Events in Children Undergoing Surgery for Oropharyngeal Cleft Deformity: A Prospective Observational Study (PRAE‐Oropharyngeal Cleft Deformity (OPCD) Study)
Authors' conclusion
Children with OPCD with higher COLDS scores and/or those with a CL grade view ≥ 3 are more likely to develop PRAE following corrective surgery.
Study context
- Population
- Children under 2 years of age undergoing elective cleft surgery for oropharyngeal cleft deformity (OPCD), May 1, 2023, to June 30, 2024of 345 operated
- Participants
- 270 participants
- Exposure
- Candidate predictors of PRAE
- Outcome
- Predictors of pre-determined PRAE (laryngospasm, bronchospasm, stridor, airway obstruction and desaturation)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Predictors of PRAE
Estimate (95% CI)P value
COLDS score ≥ 15multivariate regression
aOR 18.07(1.06–308.45)
P = 0.046CL grade ≥ 3multivariate regression
aOR 41.79(2.74–636.40)
P = 0.007COLDS scoresignificant association with PRAE
OR 0.005(0.001–0.049)
CL grade ≥ 3significant association with PRAE
OR 0.008(0.001–0.078)
Observational data: associations, not effects.
Further findings
- Overall PRAE incidence
- 1.85%
- Laryngospasm the most common PRAE
Original publication
Predictors of Perioperative Respiratory Adverse Events in Children Undergoing Surgery for Oropharyngeal Cleft Deformity: A Prospective Observational Study (PRAE‐OPCD Study). Paediatr Anaesth. Published 17 March 2025. doi:10.
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