Perioperative medicine & outcomes
Prehabilitation before pancreatoduodenectomy: results of a retrospective single-center study
Authors' conclusion
Prehabilitation is feasible and associated with improved postoperative outcomes after pancreatoduodenectomy, particularly regarding severe complications and length of hospital stay.
Study context
- Population
- Patients undergoing elective pancreatoduodenectomy116 eligible
- Participants
- 36 vs 36
- Exposure
- Multimodal home-based prehabilitation vs no prehabilitation
- Prehabilitationn = 36
- Controlsn = 36reference
- Outcome
- Postoperative complications, length of hospital stay and recovery parameters
Methodological detailssingle-center, historical control, inverse probability of treatment weighting (IPTW)-adjusted, multivariable logistic regression, Prehabilitation program January 2023-October 2024
- Single-center
- Historical control
- IPTW-adjusted
- Multivariable logistic regression
- Prehabilitation program January 2023-October 2024
Further findings
Severe complications (Clavien-Dindo 3-4)
- Significantly reduced, prehabilitation vs controls (p = 0.042)
- 16.7% vs. 38.9%
Length of hospital stay
- Shorter, prehabilitation vs controls (p = 0.017)
- 13 vs. 16 days
Postoperative complications, IPTW-adjusted
- Consistent reduction with prehabilitation (OR); statistical significance not consistently reached
- OR 0.425
- IPTW-adjusted
Complications, patients ≥ 80 years (subgroup)
- Significant reduction, prehabilitation vs controls (p = 0.028)
- 25% vs. 100%
Safety
Postoperative blood transfusion
- Lower rates, prehabilitation vs controls (p = 0.041)
- 5.6% vs. 22.2%
Original publication
Prehabilitation before pancreatoduodenectomy: results of a retrospective single-center study. Perioper Med (Lond). Published 23 April 2026. doi:10.
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