Cardiac arrest & resuscitation
Prehospital resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest (REBOARREST): an international, multicentre, open label, pragmatic, randomised, controlled trial
Primary resultResult — go to the resultAdjusted risk difference 1.8% 95% CI −11 to 15Authors' conclusion
Among patients with non-traumatic out-of-hospital cardiac arrest, a strategy of prehospital deployment of REBOA as an adjunct to ALS was feasible but did not significantly improve rates of sustained ROSC compared to ALS alone.
Study context
- Population
- Adults (18–80 years) with non-traumatic OHCA, 12 sites in Norway, Denmark and Italy179 analysed
- Participants
- 200 adults
- Comparison
- Advanced life support (ALS) combined with prehospital resuscitative endovascular balloon occlusion of the aorta (REBOA) vs ALS alone
- Interventionn = 88
- Controln = 91reference
- Primary endpoint
- Sustained return of spontaneous circulation (ROSC) (lasting ≥ 20 min), ITT population
Methodological detailspragmatic, parallel-group, multicentre, open label, blinded statistician, 21 patients dropped out due to lack of consent
- Pragmatic
- Parallel-group
- Multicentre
- Open label
- Blinded statistician
- 21 patients dropped out due to lack of consent
Primary result
As reported in the abstract
Adjusted risk difference
1.8%
95% CI −11 to 15
P = 0.78
Events by treatment group
Intervention vs Control
adjusted risk difference 1.8% (95% CI −11 to 15); P = 0.78
Further findings
Time from arrest to randomisation
Safety
- Patients with adverse events registered
- 19
Original publication
Prehospital resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest (REBOARREST): an international, multicentre, open label, pragmatic, randomised, controlled trial. Crit Care. Published 5 May 2026. doi:10.
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