Neuroanesthesia & neurocritical care
Preoperative β-Blocker Therapy and Stroke or Major Adverse Cardiac Events in Major Abdominal Surgery: A Retrospective Cohort Study
Authors' conclusion
Among patients undergoing elective major abdominal surgery, the authors observed no association between preoperative β-blocker initiation within 60 days of surgery or chronic β-blocker therapy and stroke.
Study context
- Population
- Patients undergoing elective major abdominal surgery, IBM Truven Health MarketScan 2005 to 2015 Commercial and Medicare Supplemental Databases (USA)
- Participants
- 204,981 patients
- Exposure
- Preoperative β-blocker initiation within 60 days of surgery or chronic β-blocker therapy vs β-blocker-naïve
- β-blocker initiationn = 4,026
- Chronic β-blockern = 45,424
- β-blocker-naïven = 155,531reference
- Outcome
- In-hospital stroke
Methodological detailspropensity score weighting, administrative claims databases
- Propensity score weighting
- Administrative claims databases
Main finding
As reported in the abstract
Each group vs β-blocker-naïveOdds ratio (95% CI)P value
β-blocker initiation
0.90(0.31–2.04)
P = 0.757Chronic β-blocker
0.86(0.65–1.15)
P = 0.901Observational data: associations, not effects.
Further findings
| Outcome | Chronic β-blocker | β-blocker-naïve | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACEChronic β-blocker vs β-blocker-naïve · adjusted · unadjusted absolute event rates per group | 2.6% | 0.6% | 0.81 (0.72–0.91) | P = 0.007 | |
| 0.512Odds ratio (log scale) |
Original publication
Preoperative β-Blocker Therapy and Stroke or Major Adverse Cardiac Events in Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. Published 13 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →