Neuroanesthesia & neurocritical care
Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial
Primary result · MACCEsResult — go to the resultHazard ratio 0.396 95% CI 0.187–0.838Authors' conclusion
Among patients with acute ischemic stroke complicating acute myocardial infarction, treatment with remote ischemic conditioning decreased the major adverse cardiac and cerebrovascular events and improved functional outcomes at 90 days.
Study context
- Population
- Patients with acute ischemic stroke complicating acute MI
- Participants
- 40 vs 37
- Comparison
- Remote ischemic conditioning twice daily for 2 weeks vs sham remote ischemic conditioning (RIC)
- Shamn = 40reference
- RICn = 37
- Primary endpoint
- Rate of major adverse cardiac and cerebrovascular events (MACCEs: all-cause death, unstable angina, acute myocardial infarction (AMI), acute ischemic stroke, transient ischemic attack)
- Follow-up
- 3 months
Methodological detailsdouble-blind, sham-controlled
- Double-blind
- Sham-controlled
Primary result
MACCEs
Hazard ratio
0.396
95% CI 0.187–0.838
adjusted p < 0.05
Events by treatment group
RIC vs Sham
HR 0.396 (95% CI 0.187–0.838); adjusted p < 0.05
As reported in the abstract
Further findings
| Outcome | RIC | Sham | Estimate | P value | |
|---|---|---|---|---|---|
| Death · 3 months | 16.2% | 37.5% | adjusted HR 0.333 (95% CI 0.126–0.881) | P = 0.027 | |
| Functional independence (mRS score ≤ 2) · 3 months | 45.9% | 15.0% | adjusted OR 12.75 (95% CI 2.104–77.21) | P = 0.006 | |
| 0.050.21520Ratio (log scale) |
Safety
Tolerability of procedures
- Both RIC and sham RIC procedures well tolerated
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial. Crit Care. Published 2 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →