Perioperative medicine & outcomes
Preoperative Identification of Patient-Dependent Blood Pressure Targets Associated With Low Risk of Intraoperative Hypotension During Noncardiac Surgery
Authors' conclusion
We demonstrate that IOH risk specific to a given MAP is patient-dependent, but predictable before surgery.
Study context
- Population
- Adult noncardiac surgeries under GA at 2 tertiary care hospitals of the University of Pittsburgh Medical Center
- Participants
- 166,091 surgeries
- Exposure
- Training vs Validation
- Trainingn = 121,032
- Validationn = 45,059
- Outcome
- Hypotension risk per intraoperative MAP value 65–100 mm Hg: proportion of measurements followed by ≥1 MAP <65 mm Hg within 5 or 10 minutes
Methodological detailsprediction model development and validation, 2 tertiary care hospitals
- Prediction model development and validation
- 2 tertiary care hospitals
Main finding
As reported in the abstract
- Exponential with theta constant model best fit (weighted sum of squared error)
- 0.0005
- Mean squared error of hypotension risk per MAP in validation did not exceed
- 0.01%
- Low-risk MAP targets range by subgroup and benchmark
- 69 and 90 mm Hg
- Subgroups with ≥21 eligible proportions (CI <0.05)
- Thirty-six
- Increased age, higher ASA physical status and female sex independently predicted risk curves with less rapid decay and higher plateaus
- P < .05
Observational data: associations, not effects.
Original publication
Preoperative Identification of Patient-Dependent Blood Pressure Targets Associated With Low Risk of Intraoperative Hypotension During Noncardiac Surgery. Anesth Analg. Published 18 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →