Hemodynamics, fluids & transfusion
Preoperative moderate to severe anemia is associated with increased postoperative major adverse cardiac and cerebral events and pulmonary complications: a propensity score-matched analysis in hip fracture surgery patients over 80 years old
Authors' conclusion
Moderate to severe preoperative anemia (< 11 g/dl) is associated with increased postoperative major adverse cardiac and cerebral events and pulmonary complications.
Study context
- Population
- Patients over 80 years old undergoing hip fracture surgery512 in matched cohort
- Participants
- 912 participants
- Exposure
- Preoperative moderate to severe anemia vs normal to mild anemia
- Moderate to severe anemian = 591
- Normal to mild anemian = 321reference
- Outcome
- MACCE and postoperative pulmonary complications (PPCs)
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
Moderate to severe anemia vs Normal to mild anemiaORP value
MACCE, unadjusted
1.968(96% CI 1.090–3.555)
P 0.023MACCE, adjusted
1.929(95% CI 1.014–3.668)
P 0.045PPCs, unadjusted
2.616(95% CI 1.442–4.748)
P 0.001PPCs, adjusted
2.352(95% CI 1.225–4.516)
P 0.010PPCs, propensity score-matched
3.171(95% CI 1.563–6.436)
P 0.001- Major adverse cardiac and cerebral events (MACCE), propensity score-matched; CI misprinted in abstract
- OR 2.196; P 0.027
Observational data: associations, not effects.
Further findings
In-hospital mortality
In-hospital mortality
- Not significant but higher in the moderate to severe anemia cohort
Perioperative transfusion > 2 units
- Not significantly different between the two cohorts (unadjusted)
- OR 0.967, 95% CI 0.737-1.270, P 0.811
- Not significantly different between the two cohorts (adjusted)
- OR 0.941, 95% CI 0.693-1.278, P 0.697
Delirium, gastrointestinal complication, ICU admission, deep venous thrombus (DVT)
- Similar between cohorts
Original publication
Preoperative moderate to severe anemia is associated with increased postoperative major adverse cardiac and cerebral events and pulmonary complications: a propensity score-matched analysis in hip fracture surgery patients over 80 years old. Perioper Med (Lond). Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →