Perioperative medicine & outcomes

Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications

BJA OpenPublished Clinical device trial

Main finding · POMS ≥1Result — go to the resultAdjusted odds ratio 0.94 95% CI 0.89–0.99

Authors' conclusion

Compared with structured surveys (subjective METs or Duke Activity Status Index) or conventional peak CPET values (VO2 or METs), a novel measure, GXCAP-VO2 slope, offered superior early postoperative complication discrimination in low-morbidity subjects.

Study context

Population
Adults aged >60 yr undergoing noncardiac surgery, revised cardiac risk index ≤2, self-reported METs >4
Participants
101 adults
Comparison
Submaximal cardiopulmonary exercise testing (CPET)-derived measures vs structured surveys (subjective METs, Duke Activity Status Index) for early postoperative complication detection
Outcome
Postoperative Morbidity Survey (POMS) ≥1
Methodological detailssingle-centre, open-label
  • Single-centre
  • Open-label

Main finding

POMS ≥1

Adjusted odds ratio

0.94

95% CI 0.89–0.99

P = 0.011

Submaximal CPET-derived measures vs structured surveys (subjective METs, Duke Activity Status Index) for early postoperative complication detection
aOR 0.94 (95% CI 0.89–0.99); P = 0.011

As reported in the abstract

Participants with POMS ≥1
53 (52.4%)

Secondary outcomes

Increasing LOS

aOR (95% CI)P value
GXCAP-VO2 slope0.98 (0.96–0.99)P = 0.01

Cardiac, pulmonary and renal POMS domains (POMS-CPR ≥1)

aOR (95% CI)P value
GXCAP-VO2 slope0.93 (0.88–0.99)P = 0.015

Original publication

Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open. Published 24 April 2025. doi:10.1016/j.bjao.2025.100407

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