Perioperative medicine & outcomes
Preoperative versus intraoperative antiemetic strategies in patients undergoing laparoscopic cholecystectomy: A randomised double-blind study
Authors' conclusion
Under the current study design, we found no difference in the incidence of PONV between the administration of ondansetron 1 h before induction of anaesthesia and the intraoperative administration of ondansetron 30 min before the end of surgery.
Study context
- Population
- Patients undergoing elective laparoscopic cholecystectomy, Aretaieio University Hospital, Greece
- Participants
- 121 patients
- Comparison
- Ondansetron 4 mg 1 h before induction vs 30 min before end of surgery
- Primary endpoint
- Incidence of nausea and/or vomiting combined
- Follow-up
- Up to 24 h
Methodological detailssingle-centre, double-blind, Recruited November 2018 to April 2021; follow-up up to 24 h
- Single-centre
- Double-blind
- Recruited November 2018 to April 2021; follow-up up to 24 h
Primary result
As reported in the abstract
Nausea and/or vomiting
P = 0.31
Further findings
Nausea, vomiting and retching combined · no difference
P = 0.30
Pain intensity at rest and with coughing (PACU, 4, 8 and 24 h)
- No difference between groups at rest (P = 0.961, 0.929, 0.748, 0.883) or with coughing (P = 0.974, 0.220, 0.235, 0.317)
Original publication
Preoperative versus intraoperative antiemetic strategies in patients undergoing laparoscopic cholecystectomy: A randomised double-blind study. Eur J Anaesthesiol. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →