Perioperative medicine & outcomes
Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium
Authors' conclusion
These results suggest that patients who subsequently developed delirium are more likely to be experiencing clinically silent neurodegenerative changes before surgery, reflected by changes in plasma neurofilament light chain biomarker concentrations, which may identify individuals with a preoperative vulnerability to subsequent cognitive decline.
Study context
- Population
- Patients aged 65 yr or older undergoing elective noncardiac surgery with hospital stay of 2 days or more102 vs 102 matched analysed
- Participants
- 291 patients
- Comparison
- Delirium vs No-delirium
- Deliriumn = 102
- No-deliriumn = 102reference
- Outcome
- Postoperative delirium (Confusion Assessment Method)
Methodological detailspropensity score matched by age and sex
- Propensity score matched by age and sex
Main finding
As reported in the abstract
Preoperative plasma neurofilament light chain
P = 0.02
Observational data: associations, not effects.
Further findings
Incidence of postoperative delirium, initial cohort
- Developed postoperative delirium
- 102 (35%)
Original publication
Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium. Anesthesiology. Published 7 September 2023. doi:10.
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