Prevalence and Neurological Outcomes of Comatose Patients With Extracorporeal Membrane Oxygenation
Authors' conclusion
Comaoff was common and associated with poor outcomes at discharge. Requirement of renal replacement therapy was an independent risk factor.
Study context
- Population
- Adults on venoarterial (VA) or VV extracorporeal membrane oxygenation (ECMO) at a tertiary academic hospital, November 2017 to April 02265% male
- Participants
- 230 adults
- Exposure
- VA-ECMO vs VV-ECMO
- VA-ECMOn = 143
- Outcome
- Comaoff among patients off sedation for 24 h (n = 69)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
24-h off sedation achieved
Comaon among patients unable to be sedation free for 24 h (n = 161)
Neurological outcome at discharge (modified Rankin scale; poor 4-6)
- Comaoff associated with poor outcomes in VA-ECMO and VV-ECMO
- P < 0.05
- Comaon only impacted VA-ECMO outcomes
Risk factors for comaoff (multivariable analysis)
- RRT requirement an independent risk factor for comaoff, adjusted for ECMO configuration, acute brain injury, pre-ECMO PaO2, PaCO2, pH and bicarbonate
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prevalence and Neurological Outcomes of Comatose Patients With Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. Published 6 July 2024. doi:10.
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