Pediatric anesthesia & critical care
Prevalence and Outcomes of Opioid Use Disorder in Pediatric Surgical Patients: A Retrospective Cohort Study
Authors' conclusion
OUD is becoming increasingly prevalent in adolescents presenting for surgery. Comorbid OUD is an important determinant of surgical complications, postoperative infection, and resource utilization
Study context
- Population
- US adolescents (10–18 years) undergoing inpatient surgery, 2004–2019
- Participants
- 589,098 adolescents · 563 matched pairs
- Exposure
- Comorbid opioid use disorder (OUD) vs no OUD
- OUDn = 563
- Outcome
- Inpatient mortality
Methodological details1:1 propensity score-matched, pediatric health information system
- 1:1 propensity score-matched
- Pediatric health information system
Main finding
As reported in the abstract
Inpatient mortality (univariable)
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aRR (95% CI) | P value | |
|---|---|---|---|
| Surgical complicationsPropensity-matched pairs | 1.57 (1.24–2.00) | P < 0.001 | |
| Postoperative infection | 2.02 (1.62–2.51) | P < 0.001 | |
| 0.20.5125Adjusted relative risk (log scale) |
Prevalence of OUD in adolescents undergoing surgery · 2004 to 2019
- Prevalence 2004 (per 1000 cases)
- 0.4
- Prevalence 2019 (per 1000 cases)
- 1.6
- Average annual percent change (AAPC) 9.7% (95% CI 5.7-13.9)
- P < 0.001
- Diagnosed with comorbid OUD
- 563 (0.1%)
Intensive care unit (ICU) admission, mechanical ventilation, extended postoperative length of stay (LOS)
- Increased risk with comorbid OUD
Original publication
Prevalence and Outcomes of Opioid Use Disorder in Pediatric Surgical Patients: A Retrospective Cohort Study. Anesth Analg. Published 15 April 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →