Prevalence, Risk Factors, Clinical Features, and Outcome of Influenza-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Systematic Review and Meta-Analysis
Authors' conclusion
IAPA is a common complication of severe influenza and is associated with increased mortality.
Study context
- Population
- Critically ill patients with influenza
- Participants
- 1,720 patients · 10 observational studies
- Comparison
- Influenza-associated pulmonary aspergillosis (IAPA) vs no IAPA in critically ill patients with influenza
- IAPAn = 331
- Outcome
- Prevalence of IAPA
Methodological detailsrandom effects models, one-group meta-analysis, Databases: PubMed MEDLINE, CINAHL, Cochrane Library, Embase, Scopus, Cochrane Trials, ClinicalTrials.gov
- Random effects models
- One-group meta-analysis
- Databases: PubMed MEDLINE, CINAHL, Cochrane Library, Embase, Scopus, Cochrane Trials, ClinicalTrials.gov
Pooled result
As reported in the abstract
IAPA prevalence
IAPA
19.2%
331
Further pooled results
Risk factors for IAPA
| OR (95% CI) | ||
|---|---|---|
| Organ transplantationI2 = 45% | 4.8 (1.7–13.8) | |
| Hematogenous malignancyI2 = 0% | 2.5 (1.5–4.1) | |
| ImmunocompromisedI2 = 0% | 2.2 (1.6–3.1) | |
| Prolonged corticosteroid use before admissionI2 = 51% | 2.4 (1.4–4.3) | |
| 0.050.21520Odds ratio (log scale) |
ICU mortality
| OR (95% CI) | ||
|---|---|---|
| IAPAI2 = 0% | 2.6 (1.8–3.8) | |
| 0.20.5125Odds ratio (log scale) |
Clinical and imaging features
- Commonly reported clinical and imaging features not particularly associated with IAPA
Safety
Morbidity with IAPA
- IAPA associated with more severe disease progression, higher complication rate, longer ICU stays and more organ supports
Original publication
Prevalence, Risk Factors, Clinical Features, and Outcome of Influenza-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Systematic Review and Meta-Analysis. Chest. Published 22 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →