Respiratory failure & ventilation
Prevalence, Risk Factors, and Mortality of Veno-Venous Extracorporeal Membrane Oxygenation Escalation in Acute Respiratory Distress Syndrome: A Multicenter Cohort Study From the Chinese Society of Extracorporeal Life Support Registry
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 3.444 95% CI 1.046–11.342Authors' conclusion
In this study, 4.7% of ARDS patients with venovenous ECMO underwent a mode escalation. Escalation was independently associated with higher in-hospital mortality, an association that may be partially confounded by low hospital's venovenous ECMO volume. Among the modes after escalation, venoarterial ECMO was associated with a significantly higher survival rate.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS) receiving venovenous extracorporeal membrane oxygenation (ECMO), Chinese Society of Extracorporeal Life Support registry, 112 centres across China, 2017–2023
- Participants
- 3,333 adults · 112 centres
- Exposure
- Venoarterial ECMO vs veno-veno-arterial (VVA) ECMO
- Venoarterial ECMOn = 41
- Veno-arterial-venous (VAV) ECMOn = 68
- VVA ECMOn = 48reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide registry
- Nationwide registry
Main finding
As reported in the abstract
Odds ratio
3.444
95% CI 1.046–11.342
Venoarterial ECMO vs VVA ECMO
OR 3.444 (95% CI 1.046–11.342)
- Overall in-hospital mortality
- 47.9%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Risk factors for escalation: hospital annual venovenous ECMO volume (>15 vs <6 cases per year) | 0.596 (0.382–0.930) | |
| 0.20.5125Odds ratio (log scale) |
Prevalence of escalation
- Underwent escalation
- 157 (4.7%)
Original publication
Prevalence, Risk Factors, and Mortality of Veno-Venous Extracorporeal Membrane Oxygenation Escalation in Acute Respiratory Distress Syndrome: A Multicenter Cohort Study From the Chinese Society of Extracorporeal Life Support Registry. Crit Care Med. Published 22 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →