Prevalence and Survival of Prolonged Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: An Analysis of the Extracorporeal Life Support Organization Registry*
Authors' conclusion
Prolonged VV ECMO support of ARDS has increased and accounts for a substantial portion of cases. Among patients that survive for greater than or equal to 21 days while receiving VV ECMO support, duration is not predictive of survival to hospital discharge and clinical recovery may occur even after very prolonged VV ECMO support.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS) requiring VV ECMO, Extracorporeal Life Support Organization registry, January 2012–December 2022975 supported ≥50 days
- Participants
- 13,681 adults
- Exposure
- Prolonged vs short duration of VV ECMO support
- Prolonged VV ECMOn = 4,040
- Outcome
- Mortality while on VV ECMO and survival to hospital discharge by ECMO duration
Methodological detailsregistry analysis, multivariable logistic regression
- Registry analysis
- Multivariable logistic regression
Main finding
As reported in the abstract
Survival to hospital discharge
P < 0.001
Observational data: associations, not effects.
Further findings
Mortality by duration of ECMO support, among patients on VV ECMO ≥21 days
| Estimate | P value | ||
|---|---|---|---|
| Duration of extracorporeal life supportUnadjusted · multivariable logistic regression | OR 0.99 (95% CI 0.98–1.01) | P = 0.87 | |
| Duration of extracorporeal life supportMultivariable logistic regression | adjusted OR 0.99 (95% CI 0.97–1.02) | P = 0.48 | |
| 0.512Ratio (log scale) |
| Outcome | Values |
|---|---|
| Survival to hospital discharge, VV ECMO ≥120 days | ≥120 days 46.0% |
- Survival to hospital discharge, VV ECMO ≥120 days: n = 113
Mortality by duration of ECMO support, among patients on VV ECMO ≥21 days
- Duration of ECMO support not significantly associated with mortality
Original publication
Prevalence and Survival of Prolonged Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: An Analysis of the Extracorporeal Life Support Organization Registry*. Crit Care Med. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →