Prolonged Mechanical Ventilation Prior to Venovenous Extracorporeal Membrane Oxygenation and In-Hospital Mortality in Patients With Acute Respiratory Distress Syndrome
Main finding · In-hospital mortality by duration of pre-ECMO mechanical ventilationResult — go to the resultOdds ratio 1.02 95% CI 0.98–1.06Authors' conclusion
Our study suggests that pre-ECMO mechanical ventilation duration does not independently predict mortality in patients with ARDS.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS) receiving venovenous ECMO, National Inpatient Sample, January 2019 to December 2022 (excluding ECMO before intubation, lung transplant)national estimate
- Participants
- 9,090 adults
- Exposure
- Duration of pre-ECMO mechanical ventilation
- Outcome
- In-hospital mortality
Methodological detailsNational Inpatient Sample database, survey-weighted multivariable logistic regression
- National Inpatient Sample database
- Survey-weighted multivariable logistic regression
Main finding
As reported in the abstract
In-hospital mortality by duration of pre-ECMO mechanical ventilation
Odds ratio
1.02
95% CI 0.98–1.06
P = 0.367
Duration of pre-ECMO mechanical ventilation
OR 1.02 (95% CI 0.98–1.06); P = 0.367
Observational data: associations, not effects.
Further findings
In-hospital mortality, late venovenous ECMO initiation (pre-ECMO mechanical ventilation > 7 d)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Late initiation (> 7 d)Not associated with increased risk | 1.18 (0.91–1.54) | P = 0.216 | |
| 0.512Odds ratio (log scale) |
Original publication
Prolonged Mechanical Ventilation Prior to Venovenous Extracorporeal Membrane Oxygenation and In-Hospital Mortality in Patients With Acute Respiratory Distress Syndrome. Crit Care Med. Published 18 July 2025. doi:10.
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