Prevention of ventilator-associated pneumonia by metal-coated endotracheal tubes: a meta-analysis
Authors' conclusion
Metal-coated ETT show a lower occurrence of VAP compared to the uncoated ETT. Nevertheless, they do not considerably decrease the length of mechanical ventilation, the duration of ICU admission, nor do they reduce hospital mortality rates.
Study context
- Population
- Mechanically ventilated patients with endotracheal tubes (ETTs)
- Participants
- 2,157 participants · 5 randomized controlled trials (RCTs)
- Comparison
- Metal-coated ETT vs uncoated ETT
- Outcome
- Ventilator-associated pneumonia (VAP) rate and hospital mortality
Methodological detailsDeeks funnel plot for publication bias
- Deeks funnel plot for publication bias
Pooled result
As reported in the abstract
Metal-coated ETT vs Uncoated ETTRelative risk (95% CI)P value
VAP incidence
0.71(0.54–0.95)
P = 0.02Mortality
1.05(0.86–1.27)
P = 0.65Further pooled results
Mechanical ventilation duration (2 studies)
- Mechanical ventilation duration, both patient groups: RR (95% CI), P, I2
- RR = 0.60, 95% CI (- 0.52, 1.72), P = 0.29, I2 = 97%
- No significant difference in ventilation duration between metal-coated and uncoated ETT (both studies)
- Marked heterogeneity; pooled comparison not feasible
Intensive care unit (ICU) stay (2 studies)
- ICU stay, both patient groups: RR (95% CI), P, I2
- RR = 0.47, 95% CI (- 1.02, 1.95), P = 0.54, I2 = 50%
Original publication
Prevention of ventilator-associated pneumonia by metal-coated endotracheal tubes: a meta-analysis. Crit Care. Published 17 September 2024. doi:10.
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