Respiratory failure & ventilation
Prognosis of critically ill immunocompromised patients with virus-detected acute respiratory failure
Main finding · Crude in-hospital mortality, virus-detected ARFResult — go to the resultOdds ratio 0.77 CI 0.60–0.98Authors' conclusion
In immunocompromised patients with virus-detected ARF, mortality is high, whatever the species, mainly influenced by clinical severity and poor general status. However, compared to non-viral ARF, in-hospital mortality was lower, especially for patients with detected viruses other than influenza.
Study context
- Population
- Critically ill immunocompromised patients with acute respiratory failure (ARF), 72 ICUs, 2003–2017370 virus-detected ARF
- Participants
- 4,038 participants
- Exposure
- Virus-detected ARF vs ARF from other origins
- Virus-detected ARFn = 370
- Outcome
- In-hospital mortality
Methodological detailsmulticentre database, matched cohort (1:3)
- Multicentre database
- Matched cohort (1:3)
Main finding
Crude in-hospital mortality, virus-detected ARF
Odds ratio
0.77
CI 0.60–0.98
Virus-detected ARF vs ARF from other causes
OR 0.77 (CI 0.60–0.98)
As reported in the abstract
- Crude in-hospital mortality rate
- 37.8%
- Factors associated with mortality: neutropenia
- OR = 1.74, 95% CI 1.05-2.89
- Poor performance status
- OR = 1.84, CI 1.12-3.03
- Need for invasive mechanical ventilation on day of admission
- OR = 1.97, CI 1.14-3.40
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| In-hospital mortality, influenza-like viruses (RSV, parainfluenza, human metapneumovirus) (subgroup)After matching | 0.54 (0.33–0.88) | |
| 0.20.5125Odds ratio (log scale) |
Factors associated with mortality (virus-detected ARF)
- Neutropenia, OR
- 1.74 (95% CI 1.05-2.89)
- Poor performance status, OR
- 1.84 (CI 1.12-3.03)
- Invasive mechanical ventilation on day of admission, OR
- 1.97 (CI 1.14-3.40)
- Type of virus not associated with mortality
Virus spectrum and co-infections
- Influenza
- 59%
- Respiratory syncytial virus
- 14%
- Associated bacterial infection, 79 patients
- 21%
- Invasive pulmonary aspergillosis, 23 patients
- 6%
- Significant seasonal variation
Original publication
Prognosis of critically ill immunocompromised patients with virus-detected acute respiratory failure. Ann Intensive Care. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →