Prognostic impact of Candida spp. isolation and early antifungal therapy in ICU patients with peritonitis: A multicenter cohort study
Main finding · 90-day mortalityResult — go to the resultWeighted hazard ratio 1.00 95% CI 0.62–1.59Authors' conclusion
In ICU patients with peritonitis, Candida spp. isolation in peritoneal fluid was not associated with 90-day mortality, and early antifungal therapy did not improve 90-day survival among patient with isolated Candida spp. in peritoneal fluid.
Study context
- Population
- Consecutive adults admitted with peritonitis to the ICUs of four hospitals in Western France, 2020–2022
- Participants
- 378 adults · 4 ICUs
- Exposure
- Candida spp. isolated vs No Candida spp.
- Candida spp. isolatedn = 81
- Outcome
- Mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, inverse probability treatment-weighted
- Multicentre
- Inverse probability treatment-weighted
Main finding
90-day mortality
Weighted hazard ratio
1.00
95% CI 0.62–1.59
P = 0.991
Candida spp. isolated vs No Candida spp.
weighted HR 1.00 (95% CI 0.62–1.59); P = 0.991
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Weighted HR (95% CI) | P value | |
|---|---|---|---|
| 90-day mortality, early antifungal therapy vs none (patients with Candida spp.) | 1.37 (0.58–3.22) | P = 0.470 | |
| 0.20.5125Weighted hazard ratio (log scale) |
Independent risk factors for Candida spp. isolation
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Antimicrobial therapy within last 3 months | 2.15 (1.20–3.81) | P = 0.009 | |
| Malnutrition | 1.84 (1.10–3.14) | P = 0.022 | |
| Upper gastrointestinal origin | 2.04 (1.20–3.44) | P = 0.008 | |
| Diffuse peritonitis | 1.75 (1.01–3.13) | P = 0.049 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Clinical courses
- Clinical courses similar between groups
90-day mortality, early antifungal therapy vs none (patients with Candida spp.)
- Early antifungal therapy not associated with clinical outcomes
Original publication
Prognostic impact of Candida spp. isolation and early antifungal therapy in ICU patients with peritonitis: A multicenter cohort study. Ann Intensive Care. Published 25 August 2026. doi:10.
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