Perioperative medicine & outcomes
Prognostic value of perioperative changes in serum primary metabolites in patients after major surgery under general anesthesia: an exploratory secondary analysis of the TAPIR trial
Authors' conclusion
Major abdominal surgery under general anesthesia was associated with complex changes in primary metabolites. We identified alterations in certain metabolites that were associated with postoperative delirium.
Study context
- Population
- High-risk patients undergoing major abdominal surgery under GA
- Participants
- 177 patients
- Comparison
- Serum primary metabolites on POD3 vs before surgery
- Primary endpoint
- Postoperative alterations in primary serum metabolites
- Follow-up
- POD3
Methodological detailsexploratory, targeted metabolomic analysis, false discovery rate-adjusted P values
- Exploratory
- Targeted metabolomic analysis
- False discovery rate-adjusted P values
Primary result
As reported in the abstract
Primary serum metabolites, POD3 vs before surgery
- Metabolites different on POD3 vs before surgery (of 37 analysed)
- 20
Secondary outcomes
Preoperative metabolites, patients with vs without postoperative complications (subgroup)
- No statistically significant preoperative differences
- All adjusted P values ≥ 0.05
Postoperative metabolites, patients with vs without delirium within 30 days (subgroup)
- Patients with delirium
- 13/177
- Lower alanine, asparagine, citrulline, cystine, glutamine, glutamic acid, serine, threonine, tyrosine with delirium, adjusted for preoperative levels
Original publication
Prognostic value of perioperative changes in serum primary metabolites in patients after major surgery under general anesthesia: an exploratory secondary analysis of the TAPIR trial. Can J Anaesth. Published 30 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →