ICU sedation, delirium & recovery
Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial
Authors' conclusion
ICU patients sedated with sevoflurane >48 h may return to spontaneous breathing faster, while the quality of sedation is comparable to a propofol-based sedation regime.
Study context
- Population
- Intensive-care-unit (ICU) patients requiring at least 48 h of sedationeligible to randomization
- Participants
- 79 patients
- Comparison
- Sevoflurane vs propofol/midazolam sedation
- Sn = 39
- Pn = 40reference
- Primary endpoint
- Sedation quality (Richmond-Agitation-Sedation-Scale)
Methodological detailsprospective, phase IIb, single-centre
- Prospective
- Phase IIb
- Single-centre
Primary result
As reported in the abstract
Sedation quality
- Sedation quality comparable between sevoflurane and propofol
Further findings
Time to spontaneous breathing · reduced with sevoflurane
P < 0.001
Opioid requirements
- Lower opioid requirements with propofol; remifentanil 400 μg/h vs 500 μg/h
- P = 0.007
- Sufentanil 40 μg/h vs 30 μg/h
- P = 0.007
Hemodynamics, length of stay (LOS)
- Did not differ
Safety
- Occurrence of adverse events did not differ
Original publication
Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial. J Crit Care. Published 12 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →