Vasopressor utilization in septic shock patients receiving propofol versus midazolam
Authors' conclusion
In patients with septic shock, vasopressor requirement increases with propofol were non-inferior to midazolam within the first 12 h.
Study context
- Population
- Adults (≥ 18 years) with septic shock
- Exposure
- Propofol vs midazolam sedation
- Outcome
- Maximum increase in vasopressor requirements (norepinephrine equivalents, norepinephrine equivalents (NEE)) following sedative initiation
- Follow-up
- 12 h
Methodological detailsmulticenter, observational, non-inferiority
- Multicenter
- Observational
- Non-inferiority
Main finding
As reported in the abstract
Maximum increase in NEE
P = 0.002
Observational data: associations, not effects.
Secondary outcomes
Maximum increase in NEE · 3 h · no difference
P = 0.208
Maximum increase in NEE · 6 h · significantly lower with propofol
P = 0.043
Maximum increase in NEE · 24 h · significantly lower with propofol
P = 0.013
Original publication
Vasopressor utilization in septic shock patients receiving propofol versus midazolam. J Crit Care. Published 20 October 2024. doi:10.
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