Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis
Pooled result · All-cause 90-day mortalityResult — go to the resultRelative risk 0.86 95% CrI 0.72–0.98Authors' conclusion
Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions.
Study context
- Population
- Critically ill adults with sepsis or septic shock
- Participants
- 9,108 adults · 18 RCTs
- Comparison
- Prolonged vs intermittent infusions of β-lactam antibiotics
- Outcome
- All-cause 90-day mortality
- Follow-up
- 90 days
Methodological detailsbayesian primary analysis, frequentist secondary analysis, GRADE certainty assessment
- Bayesian primary analysis
- Frequentist secondary analysis
- GRADE certainty assessment
Pooled result
As reported in the abstract
Relative risk
0.86
95% CrI 0.72–0.98
Prolonged infusions vs Intermittent infusions
RR 0.86 (95% CrI 0.72–0.98)
- Posterior probability that prolonged infusions associated with lower 90-day mortality
- 99.1%
Further pooled results
| Outcome | RR (95% CrI) | |
|---|---|---|
| ICU mortalityHigh certainty | 0.84 (0.70–0.97) | |
| Clinical cureModerate certainty | 1.16 (1.07–1.31) | |
| 0.512Relative risk (log scale) |
- Intensive care unit (ICU) mortality: 95% CrI
- Clinical cure: 95% CrI
Original publication
Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis. JAMA. Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →