Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial
Authors' conclusion
Propafenone does not provide better rhythm control at 24 h yet offers faster cardioversion with fewer arrhythmia recurrences than with amiodarone, especially in patients with a non-dilated left atrium.
Study context
- Population
- Septic shock patients with new-onset supraventricular arrhythmia and left ventricular ejection fraction above 35%200 (96%) received study drug
- Participants
- 209 patients
- Comparison
- IV propafenone vs IV amiodarone
- Primary endpoint
- Sinus rhythm 24 h after start of infusion; time to restoration of first sinus rhythm; arrhythmia recurrence
- Follow-up
- 24 h
Methodological detailsdouble-blind, two-centre, parallel group, 1:1 randomisation
- Double-blind
- Two-centre
- Parallel group
- 1:1 randomisation
Further findings
Time until cardioversion, patients with dilated left atrium (subgroup) · better rhythm control with amiodarone
P = 0.05
Original publication
Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial. Intensive Care Med. Published 12 September 2023. doi:10.
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