Pediatric anesthesia & critical care
Prophylactic application of dexmedetomidine reduces the incidence of emergence delirium in children: A systematic review and meta-analysis
Pooled resultResult — go to the resultRelative risk 0.40 95 % CI 0.30–0.55Authors' conclusion
The prophylactic use of dexmedetomidine was associated with a reduction of ED.
Study context
- Population
- Children aged 1–18 years in the PACU (6 studies eye and neck surgery, 1 hernia surgery)
- Participants
- 512 children · 7 RCTs
- Comparison
- Prophylactic dexmedetomidine vs control
- Dexmedetomidinen = 257
- Controln = 250reference
- Outcome
- Incidence of emergence delirium (ED)
Methodological detailssensitivity analysis
- Sensitivity analysis
Pooled result
As reported in the abstract
Relative risk
0.40
95 % CI 0.30–0.55
P < 0.00001
By group
Dexmedetomidine vs Control
RR 0.40 (95 % CI 0.30–0.55); P < 0.00001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| PONV | 0.24 (0.12–0.49) | P = 0.0001 | |
| 0.10.31310Relative risk (log scale) |
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| PACU stay time after extubation | −1.57 (−3.07 to −0.07) | P = 0.04 | |
| −4−202Difference (linear scale) |
PACU stay time after extubation, sensitivity analysis of RCTs
- Effect estimates not stable
- MD = −1.78 −1.78 (95%CI [−4.18-0.62], P = 0.15)
- Sensitivity analysis
Original publication
Prophylactic application of dexmedetomidine reduces the incidence of emergence delirium in children: A systematic review and meta-analysis. Anaesth Crit Care Pain Med. Published 16 September 2024. doi:10.
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