Propofol versus sevoflurane anesthesia on postoperative sleep quality in older patients after major abdominal surgery: A randomized clinical trial
Primary resultResult — go to the resultMedian difference 29 min 95 % CI 4–53Authors' conclusion
Among older patients undergoing major abdominal surgery, propofol anesthesia, compared with sevoflurane anesthesia, was associated with a longer total sleep time on the first postoperative night.
Study context
- Population
- Patients aged 65 to 90 years scheduled for elective major abdominal surgery
- Participants
- 144 patients
- Comparison
- Propofol-based IV vs sevoflurane-based inhalational anaesthesia
- Primary endpoint
- Total sleep time monitored by actigraphy
- Follow-up
- First postoperative night
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Median difference
29 min
95 % CI 4–53
P = 0.025
By group
Propofol
150
median · IQR 99–200 · min
Sevoflurane
111
IQR 80–160 · min
Propofol vs Sevoflurane
median difference 29 min (95 % CI 4–53); P = 0.025
Secondary outcomes
| Outcome | Median difference (pg/mL) (95 % CI) | P value | |
|---|---|---|---|
| Plasma orexin-A concentration · 1 h after anesthesia induction | - 31.3 (−58.1 to −2.2) | P = 0.033 | |
| Plasma orexin-A concentration · 6:00 on the first postoperative morning | - 29.8 (−58.3 to −2.3) | P = 0.036 | |
| −100−50050Difference, pg/mL (linear scale) |
Original publication
Propofol versus sevoflurane anesthesia on postoperative sleep quality in older patients after major abdominal surgery: A randomized clinical trial. J Clin Anesth. Published 2 June 2025. doi:10.
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