Respiratory failure & ventilation
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation
Authors' conclusion
The time to liberation from mechanical ventilation did not differ significantly between the group that underwent PAV+ and the group that underwent PSV.
Study context
- Population
- Adults on mechanical ventilation ≥24 hours, able to undergo partial ventilatory support with pressure-support ventilation (PSV) but not yet ready for liberation
- Participants
- 573 adults · 23 centers · 7 countries
- Comparison
- PAV+ vs PSV
- Primary endpoint
- Time from randomization to successful liberation from mechanical ventilation
Methodological detailsinternational, multicentre
- International
- Multicentre
Primary result
As reported in the abstract
P = 0.58
Secondary outcomes
Death by day 90
| Outcome | PAV+ | PSV |
|---|---|---|
| Change in midazolam-equivalent dose at day 28 vs baseline | mean −1.51 (SD 3.28) mg per kilogram of body weight | mean 0.04 (SD 0.97) mg per kilogram |
Death by day 90
- Similar in the two groups
Ventilator-free days, reintubation, tracheostomy
- Similar in the two groups
Safety
Serious adverse events
P = 0.79
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med. Published 13 June 2025. doi:10.
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